Impaired Modulation of Pain in Patients with Postherpetic Neuralgia

Fulranumab in Patients With Pain Associated With Postherpetic Neuralgia and Postraumatic Neuropathy

OBJECTIVE Fulranumab is an antibody that specifically neutralizes the biological activity of human nerve growth factor. This multicenter, phase-2, randomized, double-blind (DB), placebo-controlled study evaluated the analgesic efficacy and safety of fulranumab in postherpetic neuralgia (PHN) and posttraumatic neuropathy (PTN) patients. METHODS Patients (18 to 80 y) with inadequately controlle...

Postherpetic neuralgia.

Postherpetic Neuralgia and Trigeminal Neuralgia

Postherpetic neuralgia (PHN) is an unpredictable complication of varicella zoster virus- (VZV-) induced herpes zoster (HZ) which often occurs in elderly and immunocompromised persons and which can induce psychosocial dysfunction and can negatively impact on quality of life. Preventive options for PHN include vaccination of high-risk persons against HZ, early use of antiviral agents, and robust ...

Treatment of postherpetic neuralgia.

Herpes zoster, a commonly seen condition in daily medical practice, is reported to occur in 10–20% of the population at some time during the lifespan. Chronic, intractable postherpetic neuralgia, a sequela of herpes zoster, presents a clinical challenge. In recent years, effective antiviral agents that can be used in the outpatient setting have been developed for the treatment of herpes zoster ...

Local and Systemic Cytokine Expression in Patients with Postherpetic Neuralgia

BACKGROUND Postherpetic neuralgia (PHN) is the painful complication of a varicella zoster virus reactivation. We investigated the systemic and local gene expression of pro- and anti-inflammatory cytokine expression in patients with PHN. METHODS Thirteen patients with PHN at the torso (Th4-S1) were recruited. Skin punch biopsies were obtained from the painful and the contralateral painless bod...